| http://purl.uniprot.org/citations/20143226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20143226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20143226 | http://www.w3.org/2000/01/rdf-schema#comment | "A remarkable diversity of venom peptides is expressed in the genus Conus (known as "conotoxins" or "conopeptides"). Between 50 and 200 different venom peptides can be found in a single Conus species, each having its own complement of peptides. Conopeptides are encoded by a few gene superfamilies; here we analyze the evolution of the A-superfamily in a fish-hunting species clade, Pionoconus. More than 90 conopeptide sequences from 11 different Conus species were used to build a phylogenetic tree. Comparison with a species tree based on standard genes reveals multiple gene duplication events, some of which took place before the Pionoconus radiation. By analysing several A-conopeptides from other Conus species recorded in GenBank, we date the major duplication events after the divergence between fish-hunting and non-fish-hunting species. Furthermore, likelihood approaches revealed strong positive selection; the magnitude depends on which A-conopeptide lineage and amino-acid locus is analyzed. The four major A-conopeptide clades defined are consistent with the current division of the superfamily into families and subfamilies based on the Cys pattern. The function of three of these clades (the κA-family, the α4/7-subfamily, and α3/5-subfamily) has previously been characterized. The function of the remaining clade, corresponding to the α4/4-subfamily, has not been elucidated. This subfamily is also found in several other fish-hunting species clades within Conus. The analysis revealed a surprisingly diverse origin of α4/4 conopeptides from a single species, Conus bullatus. This phylogenetic approach that defines different genetic lineages of Conus venom peptides provides a guidepost for identifying conopeptides with potentially novel functions."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00239-010-9321-7"xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00239-010-9321-7"xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/author | "Watkins M."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/author | "Watkins M."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/author | "Puillandre N."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/author | "Puillandre N."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/name | "J. Mol. Evol."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/name | "J. Mol. Evol."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/pages | "190-202"xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/pages | "190-202"xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/title | "Evolution of conus peptide genes: duplication and positive selection in the A-Superfamily."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/title | "Evolution of conus peptide genes: duplication and positive selection in the A-Superfamily."xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/20143226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20143226 |
| http://purl.uniprot.org/citations/20143226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20143226 |
| http://purl.uniprot.org/citations/20143226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20143226 |
| http://purl.uniprot.org/citations/20143226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20143226 |