| http://purl.uniprot.org/citations/20144848 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20144848 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-myc gene is frequently overexpressed in human breast cancer and its target genes are involved in tumorigenesis. Epithelial mesenchymal transitions (EMT), where cells undergo a developmental switch from a polarized epithelial phenotype to a highly motile mesenchymal phenotype, are associated with invasion and motility of cancer cells. Basal E-cadherin expression was down-regulated in c-myc overexpressing MCF10A (c-myc-MCF10A) cells compared to GFP-overexpressing MCF10A (GFP-MCF10A) cells, while N-cadherin was distinctly increased in c-myc-MCF10A cells. Given that glycogen synthase kinase-3beta (GSK-3beta) and the snail axis have key roles in E-cadherin deregulation during EMT, we investigated the role of GSK-3beta/snail signaling pathways in the induction of EMT by c-myc overexpression. In contrast to GFP-MCF10A cells, both the transcriptional activity and the ubiquitination-dependent protein stability of snail were enhanced in c-myc-MCF10A cells, and this was reversed by GSK-3beta overexpression. We also found that c-myc overexpression inhibits GSK-3beta activity through activation of extracellular signal-regulated kinase (ERK). Inhibition of ERK by dominant negative mutant transfection or chemical inhibitor significantly suppressed snail gene transcription. These results suggest that c-myc overexpression during transformation of mammary epithelial cells (MEC) is involved in EMTs via ERK-dependent GSK-3beta inactivation and subsequent snail activation."xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2010.01.013"xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/author | "Lee W.Y."xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/author | "Cho M.K."xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/author | "Kang K.W."xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/author | "Cho K.B."xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/pages | "230-239"xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/title | "Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/20144848 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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