| http://purl.uniprot.org/citations/20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20145135 | http://www.w3.org/2000/01/rdf-schema#comment | "A-Raf belongs to the family of oncogenic Raf kinases that are involved in mitogenic signaling by activating the mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway. Low kinase activity of A-Raf toward MEK suggested that A-Raf might have alternative functions. Here, we show that A-Raf prevents cancer cell apoptosis contingent on the expression of the heterogeneous nuclear ribonucleoprotein H (hnRNP H) splice factor, which is required for the correct transcription and expression of a-raf. Apoptosis was prevented by A-Raf through sequestration and inactivation of the proapoptotic MST2 kinase. Small interfering RNA-mediated knockdown of hnRNP H or A-Raf resulted in MST2-dependent apoptosis. In contrast, enforced expression of either hnRNP H or A-Raf partially counteracted apoptosis induced by etoposide. In vivo expression studies of colon specimens corroborated the overexpression of hnRNP H in malignant tissues and its correlation with A-Raf levels. Our findings define a novel mechanism that is usurped in tumor cells to escape naturally imposed apoptotic signals."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-09-2740"xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "Gires O."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "O'Neill E."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "Mack B."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "Rauch J."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "Matthias C."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/author | "Munz M."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/pages | "1679-1688"xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/title | "Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription."xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/20145135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20145135 |
| http://purl.uniprot.org/citations/20145135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20145135 |
| http://purl.uniprot.org/uniprot/#_A0A087WZ06-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_A0A024R178-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_P10398-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_A0A384MEJ3-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3F2-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_A0A384MR07-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_B4DMG5-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |
| http://purl.uniprot.org/uniprot/#_B4DV85-mappedCitation-20145135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20145135 |