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http://purl.uniprot.org/citations/20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20150876http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The purpose of this study was to investigate the relationship between the ghrelin or GHSR-1a mRNA levels and clinical characteristics and to confirm the effect of gsp mutations on ghrelin/GHSR-1a system in human GH-secreting pituitary adenomas.

Methods

The expression levels of ghrelin, GHSR-1a mRNA were determined by SYBR green real-time fluorescent quantitative PCR. The gsp mutations in 43 cases of human GH-secreting pituitary adenomas were detected using PCR-DNA direct sequencing analysis. Clinical data were obtained from the medical records of 43 acromegalic patients who had GH and IGF-1 assays in the same laboratory.

Results

The expression of GHSR-1a correlated positvely with tumor size (R=0.411, p=0.006) and invasiveness (p<0.05). In contrast, ghrelin mRNA levels correlated positively only with tumor size (R=0.331, p=0.030) but not with tumor invasiveness (p>0.05). The expression level of GHSR-1a mRNA was significantly higher in gsp positive adenomas than in negative adenomas (p<0.05). Whereas, there was no significant difference in the expression of ghrelin mRNA between gsp mutation-positive and -negative adenomas (p>0.05). Additionally there was a significant positve correlation between the ghrelin and GHSR-1a mRNA expression levels in gsp-positive (R=0.553, p=0.040) or -negative adenomas (R=0.489, p=0.007).

Conclusions

GHSR-1a correlated positively with tumor size and invasiveness, while ghrelin correlated positively only with tumor size. Gsp mutations may upregulate the expression of GHSR-1a mRNA and have no effect on ghrelin mRNA levels in human GH-secreting pituitary adenomas."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Lei T."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Wang S."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Wang B."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Xu T."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Tian C."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Guo D."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Ye F."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/author"Shu K."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/name"Neuro Endocrinol Lett"xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/pages"147-154"xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/title"Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation."xsd:string
http://purl.uniprot.org/citations/20150876http://purl.uniprot.org/core/volume"31"xsd:string
http://purl.uniprot.org/citations/20150876http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20150876
http://purl.uniprot.org/citations/20150876http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20150876
http://purl.uniprot.org/uniprot/#_A0A0R5QLN9-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
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http://purl.uniprot.org/uniprot/#_A0A0S2Z3S5-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
http://purl.uniprot.org/uniprot/#_A0A590UJF0-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
http://purl.uniprot.org/uniprot/#_A8DN24-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
http://purl.uniprot.org/uniprot/#_A0A0S2Z3H8-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
http://purl.uniprot.org/uniprot/#_A0A7I2V5R6-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
http://purl.uniprot.org/uniprot/#_A2T3X1-mappedCitation-20150876http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20150876
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