| http://purl.uniprot.org/citations/20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20151187 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of the human immunodeficiency virus type 1 (HIV-1) Rev protein is essential for completion of the viral life cycle. Rev mediates nuclear export of partially spliced and unspliced viral transcripts and therefore bears a nuclear localization signal (NLS) as well as a nuclear export signal (NES), which allow its nucleocytoplasmic shuttling. Attempts to express the wild-type Rev protein in eukaryotic human cultured cells have encountered difficulties and so far have failed. Here we show that accumulation of Rev, which occurs in nondividing Rev-expressing cells or when such cells reach confluency, results in death of these cells. Cell death was also promoted by addition of a cell permeable peptide bearing the Rev-NES sequence, but not by the Rev-NLS peptide. Our results probably indicate that binding of excess amounts of the Rev protein or the NES peptide to the exportin receptor CRM1 results in cells' death."xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11262-010-0458-7"xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/author | "Levin A."xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/author | "Friedler A."xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/author | "Hayouka Z."xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/author | "Loyter A."xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/name | "Virus Genes"xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/pages | "341-346"xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/title | "Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/20151187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20151187 |
| http://purl.uniprot.org/citations/20151187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20151187 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V2Y6-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V461-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V6B9-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_B3KWD0-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_B4DR01-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_B7ZB16-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_O14980-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_P04618-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/#_Q77YF8-mappedCitation-20151187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/B3KWD0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20151187 |
| http://purl.uniprot.org/uniprot/A0A7I2V6B9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20151187 |