| http://purl.uniprot.org/citations/20153198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20153198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20153198 | http://www.w3.org/2000/01/rdf-schema#comment | "Hemidesmosomes connect the extracellular matrix (ECM) to intermediate filaments through ECM receptors and plakins (plectin and BPAG1e). They affect tissue integrity, wound healing, and carcinoma invasion. Although biochemical and time-lapse studies indicate that alpha6beta4-integrin (ECM receptor) and plectin play a central role in modulating hemidesmosome disassembly, the mechanisms controlling hemidesmosome biogenesis in vivo remain poorly understood. The nematode C. elegans provides a powerful genetic model to address this issue. We performed a genome-wide RNA interference screen in C. elegans, searching for genes that decrease the viability of a weak VAB-10A/plakin mutant. We identified 14 genes that have human homologs with predicted roles in different cellular processes. We further characterized two genes encoding the chaperone CRT-1/calreticulin and the HECT domain E3 ubiquitin ligase EEL-1/HUWE1. CRT-1 controls by as little as 2-fold the abundance of UNC-52/perlecan, an essential hemidesmosome ECM ligand. Likewise, EEL-1 fine tunes by 2-fold the abundance of myotactin, the putative hemidesmosome ECM receptor. CRT-1 and EEL-1 activities, and by extension other genes identified in our screen, are essential during embryonic development to enable hemidesmosomes exposed to mechanical tension to mature into a tension-resistant form. Our findings should help understand how hemidesmosome dynamics are regulated in vertebrate systems."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.12.061"xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.12.061"xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Nagamatsu Y."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Nagamatsu Y."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Labouesse M."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Labouesse M."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Diogon M."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Diogon M."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Zahreddine H."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/author | "Zahreddine H."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/pages | "322-327"xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/pages | "322-327"xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/title | "CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/title | "CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development."xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/20153198 | http://purl.uniprot.org/core/volume | "20"xsd:string |