http://purl.uniprot.org/citations/20154341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20154341 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasma homocysteine (Hcy) level is associated with cardiovascular disease and may play an etiologic role in vascular damage, a precursor for atherosclerosis. We performed a genome-wide association study for Hcy in 1786 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). The most strongly associated single-nucleotide polymorphism (SNP) (rs7422339, P = 4.7 x 10(-13)) encodes Thr1405Asn in the gene CPS1 and explained 3.0% of variation in the Hcy level. The widely studied MTHFR C677T SNP (rs1801133) was also highly significant (P = 8.7 x 10(-10)) and explained 1.6% of the trait variation. We also genotyped these two SNPs in 1679 CLHNS young adult offspring. The MTHFR C677T SNP was strongly associated with Hcy (P = 1.9 x 10(-26)) and explained approximately 5.1% of the variation in the offspring. In contrast, the CPS1 variant was significant only in females (P = 0.11 in all; P = 0.0087 in females). Combined analysis of all samples confirmed that the MTHFR variant was more strongly associated with Hcy in the offspring (interaction P = 1.2 x 10(-5)). Furthermore, although there was evidence for a positive synergistic effect between the CPS1 and MTHFR SNPs in the offspring (interaction P = 0.0046), there was no significant evidence for an interaction in the mothers (P = 0.55). These data confirm a recent finding that CPS1 is a locus influencing Hcy levels in women and suggest that genetic effects on Hcy may differ across developmental stages."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddq062"xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Levy S."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Qin L."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Mohlke K.L."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Adair L.S."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Croteau-Chonka D.C."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Kuzawa C.W."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Lange L.A."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Lange E.M."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Marvelle A.F."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Gaulton K.J."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "Borja J.B."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/author | "McDade T.W."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/pages | "2050-2058"xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/title | "Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults."xsd:string |
http://purl.uniprot.org/citations/20154341 | http://purl.uniprot.org/core/volume | "19"xsd:string |
http://purl.uniprot.org/citations/20154341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20154341 |
http://purl.uniprot.org/citations/20154341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20154341 |
http://purl.uniprot.org/uniprot/#_A0A1C9J7R9-mappedCitation-20154341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20154341 |