| http://purl.uniprot.org/citations/20155810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20155810 | http://www.w3.org/2000/01/rdf-schema#comment | "Upregulation of haptoglobin (Hp) expression in the rat during the acute phase (AP) response is the result of synergistic effects of IL-6-, IL-1beta-, and corticosterone-activated signaling pathways. IL-6 signaling terminates in cis-trans interactions of the Hp gene hormone-responsive element (HRE) with transcription factors STAT3 and C/EBPbeta. The aim of this study was to examine the unresolved molecular mechanism of glucocorticoid action. A 3-fold rise in serum corticosterone at 2 and 4 h of the AP response induced by turpentine administration preceded a 2.3-fold increase in the rate of Hp gene transcription at 12 h that was accompanied by a 4.8-fold increase in glucocorticoid receptor (GR), the appearance of an 86-kDa STAT3 isoform and 3.9-, 1.9-, and 1.7-fold increased amounts of 91-kDa STAT3, 35- and 42-kDa C/EBPbeta isoforms in the nucleus. These events resulted in 4.6- and 2.5-fold increased Hp levels in the liver and serum at 24 h. HRE affinity chromatography and immunoblot analysis revealed that maximal occupancy of the HRE with GR, STAT3, and C/EBPbeta at 12 h correlated with increased transcriptional activity of the Hp gene. Coimmunoprecipitation experiments showed that activated GR established de novo interaction with STAT3 isoforms while GR-C/EBPbeta interactions observed during basal transcription increased during the AP response. Computer analysis of the HRE disclosed two potential GR-binding sites: one overlapping STAT3, another adjacent to a C/EBPbeta-binding site. This finding and the experimental results suggest that activated GR through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.org/dc/terms/identifier | "doi:10.1002/iub.313"xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Grigorov I."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Poznanovic G."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Uskokovic A."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Bogojevic D."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Ivanovic-Matic S."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Mihailovic M."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/author | "Arambasic J."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/name | "IUBMB Life"xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/pages | "227-236"xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/title | "Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response."xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/20155810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20155810 |
| http://purl.uniprot.org/citations/20155810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20155810 |
| http://purl.uniprot.org/uniprot/P21272#attribution-1DD83A8C2CB6CB815E3B48DDE83E807C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20155810 |
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| http://purl.uniprot.org/uniprot/#_P52631-mappedCitation-20155810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20155810 |
| http://purl.uniprot.org/uniprot/#_A6J3I0-mappedCitation-20155810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20155810 |
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| http://purl.uniprot.org/uniprot/#_A8IRI3-mappedCitation-20155810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20155810 |