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http://purl.uniprot.org/citations/20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20157760http://www.w3.org/2000/01/rdf-schema#comment"

Objective

This study was designed to evaluate whether interleukin-23 receptor (IL-23R) polymorphisms were associated with Crohn's disease (CD) susceptibility.

Methods

PubMed, MEDLINE, and Embase were searched for studies that investigated the IL-23R variants and CD risk. Meta-analysis from all eligible case-control studies was performed to assess the purported associations.

Results

Our analysis found that variant minor alleles for single nucleotide polymorphisms (SNPs) rs11209026 (Arg381Gln) (P < 0.00001, OR = 0.43, 95% CI (0.37-0.50)) and rs7517847 (G/G vs. T/T, P < 0.00001, OR = 0.49, 95% CI (0.38-0.64); G/G vs. T/G + T/T, (P < 0.00001, OR = 0.56, 95% CI (0.44-0.72); T/G + G/G vs. T/T, (P < 0.00001, OR = 0.71, 95% CI (0.64-0.79) of IL-23R were inversely associated with CD risk; sensitivity analysis also indicated that Caucasian population with a variant of Arg381Gln has a decreased risk for developing CD (P < 0.00001, OR = 0.43, 95% CI (0.36-0.50)).

Conclusion

Our meta-analysis supports that two polymorphisms (Arg381Gln and rs7517847) within the IL-23R gene may be considered to be protective factors against developing CD. Further large case-control studies especially concerning ethnicity differences and genotype-phenotype interaction should be performed to clarify possible roles of IL-23R in CD."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.org/dc/terms/identifier"doi:10.1007/s00011-010-0171-y"xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Shen L."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Tian Y."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Yu C."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Li J.S."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Mao Q."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/author"Zhu W.M."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/name"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/pages"607-614"xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/title"Interleukin-23 receptor genetic polymorphisms and Crohn's disease susceptibility: a meta-analysis."xsd:string
http://purl.uniprot.org/citations/20157760http://purl.uniprot.org/core/volume"59"xsd:string
http://purl.uniprot.org/citations/20157760http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20157760
http://purl.uniprot.org/citations/20157760http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20157760
http://purl.uniprot.org/uniprot/#_D9N2T9-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY72-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY73-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY74-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY75-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY76-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY77-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
http://purl.uniprot.org/uniprot/#_B6HY78-mappedCitation-20157760http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20157760
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