| http://purl.uniprot.org/citations/20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20159461 | http://www.w3.org/2000/01/rdf-schema#comment | "A-kinase anchoring proteins (AKAPs) regulate cyclic AMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP 2 (D-AKAP2) binds to the dimerization/docking (D/D) domain of both RI and RII regulatory subunits of PKA with high affinity. Here we have determined the structures of the RIalpha D/D domain alone and in complex with D-AKAP2. The D/D domain presents an extensive surface for binding through a well-formed N-terminal helix, and this surface restricts the diversity of AKAPs that can interact. The structures also underscore the importance of a redox-sensitive disulfide in affecting AKAP binding. An unexpected shift in the helical register of D-AKAP2 compared to the RIIalpha:D-AKAP2 complex structure makes the mode of binding to RIalpha novel. Finally, the comparison allows us to deduce a molecular explanation for the sequence and spatial determinants of AKAP specificity."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2009.12.012"xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "Taylor S.S."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "Wang B.C."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "Kim C."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "Sarma G.N."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "von Daake S."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/author | "Kinderman F.S."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/pages | "155-166"xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/title | "Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity."xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/20159461 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20159461 |
| http://purl.uniprot.org/citations/20159461 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20159461 |
| http://purl.uniprot.org/uniprot/P00514#attribution-255476B088AE2A95CD87BEC723630D06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Y8-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Z7-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z513-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z551-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z5A1-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_B7Z2W6-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |
| http://purl.uniprot.org/uniprot/#_E7EMD6-mappedCitation-20159461 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159461 |