| http://purl.uniprot.org/citations/20159957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20159957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20159957 | http://www.w3.org/2000/01/rdf-schema#comment | "The orphan receptor LRH-1 and the oxysterol receptors LXRalpha and LXRbeta are established transcriptional regulators of lipid metabolism that appear to control inflammatory processes. Here, we investigate the anti-inflammatory actions of these nuclear receptors in the hepatic acute phase response (APR). We report that selective synthetic agonists induce SUMOylation-dependent recruitment of either LRH-1 or LXR to hepatic APR promoters and prevent the clearance of the N-CoR corepressor complex upon cytokine stimulation. Investigations of the APR in vivo, using LXR knockout mice, indicate that the anti-inflammatory actions of LXR agonists are triggered selectively by the LXRbeta subtype. We further find that hepatic APR responses in small ubiquitin-like modifier-1 (SUMO-1) knockout mice are increased, which is due in part to diminished LRH-1 action at APR promoters. Finally, we provide evidence that the metabolically important coregulator GPS2 functions as a hitherto unrecognized transrepression mediator of interactions between SUMOylated nuclear receptors and the N-CoR corepressor complex. Our study extends the knowledge of anti-inflammatory mechanisms and pathways directed by metabolic nuclear receptor-corepressor networks to the control of the hepatic APR, and implies alternative pharmacological strategies for the treatment of human metabolic diseases associated with inflammation."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.545110"xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.545110"xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Treuter E."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Treuter E."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Jaenne O.A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Jaenne O.A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Ellis E."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Ellis E."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Nilsson L.M."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Nilsson L.M."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Steffensen K.R."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Steffensen K.R."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Damdimopoulos A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Damdimopoulos A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Ehrlund A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Ehrlund A."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Jakobsson T."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Jakobsson T."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Mikkonen L."xsd:string |
| http://purl.uniprot.org/citations/20159957 | http://purl.uniprot.org/core/author | "Mikkonen L."xsd:string |