| http://purl.uniprot.org/citations/20159958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20159958 | http://www.w3.org/2000/01/rdf-schema#comment | "Commissural axon guidance requires complex modulations of growth cone sensitivity to midline-derived cues, but underlying mechanisms in vertebrates remain largely unknown. By using combinations of ex vivo and in vivo approaches, we uncovered a molecular pathway controlling the gain of response to a midline repellent, Semaphorin3B (Sema3B). First, we provide evidence that Semaphorin3B/Plexin-A1 signaling participates in the guidance of commissural projections at the vertebrate ventral midline. Second, we show that, at the precrossing stage, commissural neurons synthesize the Neuropilin-2 and Plexin-A1 Semaphorin3B receptor subunits, but Plexin-A1 expression is prevented by a calpain1-mediated processing, resulting in silencing commissural responsiveness. Third, we report that, during floor plate (FP) in-growth, calpain1 activity is suppressed by local signals, allowing Plexin-A1 accumulation in the growth cone and sensitization to Sema3B. Finally, we show that the FP cue NrCAM mediates the switch of Plexin-A1 processing underlying growth cone sensitization to Sema3B. This reveals pathway-dependent modulation of guidance receptor processing as a novel mechanism for regulating guidance decisions at intermediate targets."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.542510"xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Okuno T."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Yoshida Y."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Clark C."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Takamatsu H."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Takeshima K."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Bozon M."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Kumanogoh A."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Briancon-Marjollet A."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Castellani V."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Moret F."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Nawabi H."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Abouzid K."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/author | "Sanyas I."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/pages | "396-410"xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/title | "A midline switch of receptor processing regulates commissural axon guidance in vertebrates."xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/20159958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20159958 |
| http://purl.uniprot.org/citations/20159958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20159958 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YW56-mappedCitation-20159958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159958 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDD7-mappedCitation-20159958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159958 |