| http://purl.uniprot.org/citations/20159973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20159973 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomeres are repetitive nucleoprotein structures that cap the ends of chromosomes. Without telomerase, telomeres shorten with replication and eventually signal cell cycle arrest (cell senescence). Homologous recombination (HR)-based mechanisms slow senescence, and distinct HR mechanisms support the growth of the rare survivors of senescence. Here, we report novel roles for the post-translational modification of small ubiquitin-like modifier (SUMO) in regulating the rate of senescence in Saccharomyces cerevisiae telomerase mutants. We identify Mms21 as the relevant SUMO E3 ligase and demonstrate that cells lacking Mms21-dependent sumoylation accumulate HR intermediates selectively at telomeres during senescence. One target of Mms21-dependent sumoylation is the cohesin- and condensin-related Smc5-Smc6 complex (Smc5/6). We show that hypomorphic smc5 or smc6 alleles exhibit phenotypes similar to mms21 sumoylation-deficient mutants with regard to senescence and the accumulation of unresolved HR intermediates. Further, we provide evidence that Mms21 and Smc5/6 prevent aberrant recombination between sister telomeres and also globally facilitate resolution of sister chromatid HR intermediates."xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.041277"xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/author | "Johnson F.B."xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/author | "Chavez A."xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/author | "Agrawal V."xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/author | "George V."xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/pages | "11922-11930"xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/title | "Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution."xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20159973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20159973 |
| http://purl.uniprot.org/citations/20159973 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20159973 |
| http://purl.uniprot.org/uniprot/Q08204#attribution-06C665487F79C3BBBE165EEA16DB655A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20159973 |
| http://purl.uniprot.org/uniprot/Q12749#attribution-06C665487F79C3BBBE165EEA16DB655A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20159973 |
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| http://purl.uniprot.org/uniprot/#_A0A6V8S000-mappedCitation-20159973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159973 |
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| http://purl.uniprot.org/uniprot/#_Q08204-mappedCitation-20159973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159973 |
| http://purl.uniprot.org/uniprot/#_Q12749-mappedCitation-20159973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20159973 |
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| http://purl.uniprot.org/uniprot/Q08204 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20159973 |
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