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http://purl.uniprot.org/citations/20160193http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20160193http://www.w3.org/2000/01/rdf-schema#comment"

Background

Although epidemiological studies have demonstrated an increased predisposition to low high-density lipoprotein cholesterol and high triglyceride levels in the Mexican population, Mexicans have not been included in any of the previously reported genome-wide association studies for lipids.

Methods and results

We investigated 6 single-nucleotide polymorphisms associated with triglycerides, 7 with high-density lipoprotein cholesterol, and 1 with both triglycerides and high-density lipoprotein cholesterol in recent Caucasian genome-wide association studies in Mexican familial combined hyperlipidemia families and hypertriglyceridemia case-control study samples. These variants were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2. We performed a combined analysis of the family-based and case-control studies (n=2298) using the Z method to combine statistics. Ten of the single-nucleotide polymorphisms were nominally significant and 5 were significant after Bonferroni correction (P=2.20 x 10(-3) to 2.6 x 10(-11)) for the number of tests performed (APOA5, CETP, GCKR, and GALNT2). Interestingly, our strongest signal was obtained for triglycerides with the minor allele of rs964184 (P=2.6 x 10(-11)) in the APOA1/C3/A4/A5 gene cluster region that is significantly more common in Mexicans (27%) than in whites (12%).

Conclusions

It is important to confirm whether known loci have a consistent effect across ethnic groups. We show replication of 5 Caucasian genome-wide association studies lipid associations in Mexicans. The remaining loci will require a comprehensive investigation to exclude or verify their significance in Mexicans. We also demonstrate that rs964184 has a large effect (odds ratio, 1.74) and is more frequent in the Mexican population, and thus it may contribute to the high predisposition to dyslipidemias in Mexicans."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.org/dc/terms/identifier"doi:10.1161/circgenetics.109.908004"xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Weissglas-Volkov D."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Tusie-Luna T."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Ordonez-Sanchez M.L."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Riba L."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Cantor R.M."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Sinsheimer J.S."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Pajukanta P."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Huertas-Vazquez A."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Aguilar-Salinas C.A."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/author"Rodriguez-Guillen R."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/name"Circ Cardiovasc Genet"xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/pages"31-38"xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/title"Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples."xsd:string
http://purl.uniprot.org/citations/20160193http://purl.uniprot.org/core/volume"3"xsd:string
http://purl.uniprot.org/citations/20160193http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20160193
http://purl.uniprot.org/citations/20160193http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20160193
http://purl.uniprot.org/uniprot/#_A8K2M5-mappedCitation-20160193http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20160193
http://purl.uniprot.org/uniprot/#_P11150-mappedCitation-20160193http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20160193
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