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http://purl.uniprot.org/citations/20160197http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20160197http://www.w3.org/2000/01/rdf-schema#comment"

Background

We previously mapped a quantitative trait locus on chromosome 15 in mice contributing to high-density lipoprotein cholesterol and triglyceride levels and now report the identification of the underlying gene.

Methods and results

We first fine-mapped the locus by studying a series of congenic strains derived from the parental strains BALB/cJ and MRL/MpJ. Analysis of gene expression and sequencing followed by transgenic complementation led to the identification of zinc fingers and homeoboxes 2 (Zhx2), a transcription factor previously implicated in the developmental regulation of alpha-fetoprotein. Reduced expression of the protein in BALB/cJ mice resulted in altered hepatic transcript levels for several genes involved in lipoprotein metabolism. Most notably, the Zhx2 mutation resulted in a failure to suppress expression of lipoprotein lipase, a gene normally silenced in the adult liver, and this was normalized in BALB/cJ mice carrying the Zhx2 transgene.

Conclusions

We identified the gene underlying the chromosome 15 quantitative trait locus, and our results show that Zhx2 functions as a novel developmental regulator of key genes influencing lipoprotein metabolism."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.org/dc/terms/identifier"doi:10.1161/circgenetics.109.902320"xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Lusis A.J."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Gargalovic P.S."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Kohannim O."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Pagnon J."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Castellani L."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Peterson M.L."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Spear B.T."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"Erbilgin A."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/author"LeBoeuf R."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/name"Circ Cardiovasc Genet"xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/pages"60-67"xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/title"Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism."xsd:string
http://purl.uniprot.org/citations/20160197http://purl.uniprot.org/core/volume"3"xsd:string
http://purl.uniprot.org/citations/20160197http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20160197
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http://purl.uniprot.org/uniprot/Q3TZR8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20160197
http://purl.uniprot.org/uniprot/Q8C0C0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20160197