| http://purl.uniprot.org/citations/20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20164027 | http://www.w3.org/2000/01/rdf-schema#comment | "STAT3 contributes to increase of EPO expression which is also HIF-1 dependent. EPO receptor activates STAT3. Expressions of STAT3 and hypoxia induced proteins: HIF-1, EPO and EPOR show mutual correlations in primary ductal breast cancers, which suggest co-operation among these proteins. Moreover, EPO-EPOR signaling was reported to mediate cell survival by targeting Bcl-xL in competition with Bax-dependent apoptosis. Our present study was focused on immunohistochemical evaluation of STAT3, HIF-1alpha, EPO and EPOR in relation to apoptosis regulators, Bax and Bcl-xL in 39 metastases of ductal breast cancers to lymph nodes. The proteins were abundantly expressed by cancer cells. HIF-1alpha correlated with EPOR in all and in chemotherapy treated metastases (r=0.428, p=0.007 and r=0.462, p=0.040, respectively). HIF-1 associated significantly with EPO in chemotherapy spared metastases (r=0.549, p=0.015) and comparison between those proteins almost reached statistical significance in entire number of metastatic breast cancers (r=0.309, p=0.056). Metastases from T2 primary tumors had significantly higher expressions of HIF-1alpha, EPO and EPOR compared to T1 originating metastases (p=0.020, p=0.028, p=0.021, respectively). Bax correlated with EPO and EPOR in all studied nodal metastases (r=0.449, p=0.006 and r=0.421, p=0.011, respectively) and so did Bcl-xL with HIF-1alpha (r=0.440, p=0.007), EPO and EPOR (r=0.383, p=0.021, r=0.495, p=0.002, respectively). Metastatic breast cancers seem to be areas of intensive signaling by STAT3, HIF-1, EPO and EPOR. Strong Bax and Bcl-xL labeling reflects accelerated cell turnover in nodal metastases. By means of association with Bcl-xL, HIF-1alpha, EPO and EPOR could favor growth of nodal metastases and survival of breast cancers cells."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.org/dc/terms/identifier | "doi:10.2478/v10042-009-0099-7"xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/author | "Koda M."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/author | "Kanczuga-Koda L."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/author | "Sulkowska M."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/author | "Sulkowski S."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/author | "Wincewicz A."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/author | "Wincewicz D."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/name | "Folia Histochem Cytobiol"xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/pages | "425-430"xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/title | "STAT3 and hypoxia induced proteins--HIF-1alpha, EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers."xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/20164027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20164027 |
| http://purl.uniprot.org/citations/20164027 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20164027 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A9QVL7-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDC9-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDD6-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDD9-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDE0-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDE1-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDF3-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |
| http://purl.uniprot.org/uniprot/#_A0A6G6CDG2-mappedCitation-20164027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20164027 |