| http://purl.uniprot.org/citations/20167579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20167579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20167579 | http://www.w3.org/2000/01/rdf-schema#comment | "Axonal transport and translation of beta-actin mRNA plays an important role for axonal growth and presynaptic differentiation in many neurons including hippocampal, cortical and spinal motor neurons. Several beta-actin mRNA-binding and transport proteins have been identified, including ZBP1, ZBP2 and hnRNP-R. hnRNP-R has been found as an interaction partner of the survival motor neuron protein that is deficient in spinal muscular atrophy. Little is known about the function of hnRNP-R in axonal beta-actin translocation. hnRNP-R and beta-actin mRNA are colocalized in axons. Recombinant hnRNP-R interacts directly with the 3'-UTR of beta-actin mRNA. We studied the role of hnRNP-R in motor neurons by knockdown in zebrafish embryos and isolated mouse motor neurons. Suppression of hnRNP-R in developing zebrafish embryos results in reduced axon growth in spinal motor neurons, without any alteration in motor neuron survival. ShRNA-mediated knockdown in isolated embryonic mouse motor neurons reduces beta-actin mRNA translocation to the axonal growth cone, which is paralleled by reduced axon elongation. Dendrite growth and neuronal survival were not affected by hnRNP-R depletion in these neurons. The loss of beta-actin mRNA in axonal growth cones of hnRNP-R-depleted motor neurons resembles that observed in Smn-deficient motor neurons, a model for the human disease spinal muscular atrophy. In particular, hnRNP-R-depleted motor neurons also exhibit defects in presynaptic clustering of voltage-gated calcium channels. Our data suggest that hnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddq073"xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Winkler C."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Winkler C."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Herrmann T."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Herrmann T."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Sendtner M."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Sendtner M."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Rossoll W."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Rossoll W."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Havlicek S."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Havlicek S."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Funk N."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Funk N."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Glinka M."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/author | "Glinka M."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/pages | "1951-1966"xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/pages | "1951-1966"xsd:string |
| http://purl.uniprot.org/citations/20167579 | http://purl.uniprot.org/core/title | "The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons."xsd:string |