| http://purl.uniprot.org/citations/20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20171103 | http://www.w3.org/2000/01/rdf-schema#comment | "The establishment and maintenance of proper attachment of kinetochores to microtubules are required to prevent chromosome missegregation and consequent chromosomal instability and tumorigenesis. Although MST1 (mammalian sterile 20-like kinase 1) has been implicated in many aspects of cell cycle regulation and tumor suppression [1], its precise mechanism of action has remained largely unknown. We now show that MST1 promotes accurate kinetochore-microtubule attachment by modulating the kinase activity of Aurora B. HeLa cells depleted of MST1 failed to develop stable end-on kinetochore-microtubule attachment, giving rise to unaligned mitotic chromosomes. The misaligned chromosomes activated the Mad2- and BubR1-dependent spindle checkpoint response, resulting in a delay in anaphase onset. The kinase activity of Aurora B, which promotes destabilization of kinetochore-microtubule attachment [2-4], was increased in cells depleted of MST1 or NDR1, a downstream kinase of MST1. MST1 and NDR1 associated with Aurora B. Moreover, MST1 directly phosphorylated Aurora B and inhibited its kinase activity in vitro. Depletion of Aurora B restored the stability of kinetochore-microtubule attachment in cells depleted of MST1 or NDR1. MST1 is thus a key regulator of Aurora B activity that ensures mitotic chromosome congression and accurate chromosome segregation."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2009.12.054"xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Kwon S.H."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Choi E.J."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Kim T."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Oh H.J."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Lim D.S."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/author | "Song S.J."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/pages | "416-422"xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/title | "MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment."xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/20171103 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20171103 |
| http://purl.uniprot.org/citations/20171103 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20171103 |
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| http://purl.uniprot.org/uniprot/#_A2A5M9-mappedCitation-20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171103 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQE0-mappedCitation-20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171103 |
| http://purl.uniprot.org/uniprot/#_B2RC06-mappedCitation-20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171103 |
| http://purl.uniprot.org/uniprot/#_A0PJ51-mappedCitation-20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171103 |
| http://purl.uniprot.org/uniprot/#_D6RHQ9-mappedCitation-20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171103 |
| http://purl.uniprot.org/uniprot/#_F7BYZ4-mappedCitation-20171103 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171103 |