| http://purl.uniprot.org/citations/20171739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20171739 | http://www.w3.org/2000/01/rdf-schema#comment | "Poly(ADP-ribose) polymerase-1 (Parp-1) is a nuclear enzyme that uses NAD(+) as a substrate to catalyze the addition of ADP-ribose polymers on a variety of nuclear proteins, modifying transiently their biological functions. Parp-1 has been involved in transcription regulation of many genes involved in the inflammatory response including cytokines and chemokines. Accordingly, genetic deletion of Parp-1 (Parp-1(-/-)) or pharmacological blockade of Parp-1 activity in mice results in a defective inflammatory immune response which confers an advantage in different pathophysiological conditions associated with inflammation. In addition to the transcriptional control, increasing mRNA stability, mainly through the mitogen-activated protein kinase p38 (p38(MAPK)) might be an important mechanism for the tight regulation in the expression of several chemokines such as IP-10. Here we demonstrate that Parp-1 deficiency in embryonic fibroblasts results in diminished IFN-gamma-induced IP-10 expression despite normal STAT1 activation and IP-10 promoter activity. Therefore, we have analyzed the involvement of Parp-1 in IP-10 mRNA stability. Parp-1 deficient cells showed a decreased half-life of IFN-gamma-induced IP-10 transcripts associated with a defect in p38(MAPK) activation. Our results demonstrate that Parp-1 can regulate inflammatory gene expression by increasing mRNA stability, via modulating a proper p38(MAPK) signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2010.01.022"xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/author | "Ramirez P."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/author | "Galbis-Martinez M."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/author | "Yelamos J."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/author | "Saenz L."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/author | "Parrilla P."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/pages | "1492-1499"xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/title | "Poly(ADP-ribose) polymerase-1 modulates interferon-gamma-inducible protein (IP)-10 expression in murine embryonic fibroblasts by stabilizing IP-10 mRNA."xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/20171739 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20171739 |
| http://purl.uniprot.org/citations/20171739 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20171739 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YX03-mappedCitation-20171739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171739 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY63-mappedCitation-20171739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20171739 |
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