| http://purl.uniprot.org/citations/20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20173025 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine, produced by epithelial cells, that has been linked to atopic dermatitis and asthma; however, it remains unclear how TSLP shapes the adaptive immune response that causes these allergic disorders. In this study, we demonstrate a role for TSLP in a Th2 model of contact hypersensitivity in mice. TSLP is required for the development of Th2-type contact hypersensitivity induced by the hapten FITC in combination with the sensitizing agent dibutyl phthalate. TSLPR-deficient mice exhibited a dramatically reduced response, including markedly reduced local infiltration by eosinophils, Th2 cytokine production, and serum IgE levels, following FITC sensitization and challenge. The reduced response by TSLPR-deficient mice is likely due to decreased frequency and reduced T cell stimulatory function of skin-derived Ag-bearing FITC(+)CD11c(+) dendritic cells in draining lymph nodes following FITC sensitization. These data suggest that skin-derived dendritic cells are direct or indirect targets of TSLP in the development of type 2 immune responses in the skin, where TSLP drives their maturation, accumulation in skin draining lymph nodes, and ability to induce proliferation of naive allergen-specific T cells."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803478"xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Hauser C."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Iseki M."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Comeau M.R."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Omori M."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Itano A."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Larson R.P."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/author | "Zimmerli S.C."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/pages | "2974-2984"xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/title | "Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses."xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20173025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20173025 |
| http://purl.uniprot.org/citations/20173025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20173025 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGP1-mappedCitation-20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20173025 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0F5-mappedCitation-20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20173025 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF13-mappedCitation-20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20173025 |
| http://purl.uniprot.org/uniprot/#_Q05DC7-mappedCitation-20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20173025 |
| http://purl.uniprot.org/uniprot/#_Q3TCZ1-mappedCitation-20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20173025 |
| http://purl.uniprot.org/uniprot/#_Q8CII9-mappedCitation-20173025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20173025 |
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