| http://purl.uniprot.org/citations/20175115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20175115 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor (TGF)-beta is secreted and targeted into the extracellular matrix (ECM) in association with one of the latent TGF-beta binding proteins (LTBPs). Activation of these latent complexes is an important regulatory step in TGF-beta signaling. LTBPs target the growth factor into the ECM and expose it to activating mechanisms. Disruption of LTBP-4 gene causes severe developmental abnormalities in both humans and mice. Transcripts for two N-terminally distinct LTBP-4 variants, LTBP-4S (short) and -4L (long), have been identified. In the current work, we have characterized differences in the expression, processing, and ECM targeting of these LTBP-4 variants. Heart and skeletal muscle displayed expression of both variants, while liver expressed mainly LTBP-4L and lung as well as small intestine LTBP-4S. This tissue-specific expression pattern was found to originate from control of transcription by two independent promoters. Furthermore, LTBP-4S and -4L proteins were secreted and processed differently. During secretion, LTBP-4L was complexed with TGF-beta1, whereas the majority of LTBP-4S was secreted in a free form. In addition, LTBP-4S was incorporated into the ECM, while full-length LTBP-4L was not readily detectable in the ECM. These data suggest that LTBP-4 functions are modified by tissue-specific expression of the two N-terminally distinct variants, which in addition exhibit significant differences in cellular processing and targeting, that is, this provides a basis for understanding molecular diversity in LTBP-4 structure and function."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.22082"xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/author | "Koli K."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/author | "Keski-Oja J."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/author | "Ryynanen M.J."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/author | "Kantola A.K."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/author | "Lhota F."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/pages | "727-736"xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/title | "Independent regulation of short and long forms of latent TGF-beta binding protein (LTBP)-4 in cultured fibroblasts and human tissues."xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://purl.uniprot.org/core/volume | "223"xsd:string |
| http://purl.uniprot.org/citations/20175115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20175115 |
| http://purl.uniprot.org/citations/20175115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20175115 |
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