| http://purl.uniprot.org/citations/20177144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20177144 | http://www.w3.org/2000/01/rdf-schema#comment | "Transglutaminase 4 is a member of enzyme family that catalyzes calcium-dependent posttranslational modification of proteins. Although transglutaminase 4 has been shown to have prostate-restricted expression pattern, little is known about the biological function of transglutaminase 4 in human. To gain insight into its role in prostate, we analyzed the expression status of human transglutaminase 4 in benign prostate hyperplasia (BPH) and prostate cancer (PCa). Unexpectedly, RT-PCR and nucleotide sequence analysis showed four alternative splicing variants of transglutaminase 4: transglutaminase 4-L, -M (-M1 and -M2) and -S. The difference between transglutaminase 4-M1 and -M2 is attributed to splicing sites, but not nucleotide size. The deduced amino acid sequences showed that transglutaminase 4-L, -M1 and -M2 have correct open reading frames, whereas transglutaminase 4-S has a truncated reading frame. RT-PCR analysis of clinical samples revealed that transglutaminase 4-M and -S were detected in all tested prostate tissue (80 BPH and 48 PCa). Interestingly, transglutaminase 4-L was found in 56% of BPH (45 out of 80) and only in 15% of PCa (7 out of 48). However, transglutaminase 4-L expression did not correlate with serum prostate-specific antigen (PSA) level, prostate volumes or PSA densities. These results will provide a clue to future investigation aiming at delineating physiological and pathological roles of human transglutaminase 4."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.org/dc/terms/identifier | "doi:10.3858/emm.2010.42.4.031"xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Lee J.B."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Jeon J.H."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Kim C.W."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Kim C.S."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Lee S.E."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Song K.Y."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Shin D.M."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Cho S.Y."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Kim I.G."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Jeong E.M."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/author | "Jang G.Y."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/pages | "310-318"xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/title | "Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/20177144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20177144 |
| http://purl.uniprot.org/citations/20177144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20177144 |
| http://purl.uniprot.org/uniprot/#_A0A994J576-mappedCitation-20177144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177144 |
| http://purl.uniprot.org/uniprot/#_B2R7D1-mappedCitation-20177144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177144 |