| http://purl.uniprot.org/citations/20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20177805 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factor 1 (IRF-1) is a transcription factor that has been implicated in the disease mechanisms of experimental autoimmune encephalomyelitis (EAE). In this study, we examined the role of central nervous system (CNS) expression of IRF-1 in the natural course of EAE. In an effort to dissect the CNS effects from the peripheral immune effects of IRF-1, we generated bone marrow chimera mice that differentially expressed IRF-1 in the CNS and in the immune system. We found that mice lacking IRF-1 in the CNS developed significantly milder clinical symptoms and shorter disease duration compared to those with wild-type background. Based on these results, we concluded that the CNS expression of IRF-1 regulates the disease process in EAE. Our findings are relevant to the inflammatory mechanisms involved in multiple sclerosis and may provide a basis for development of novel therapeutic targets of the disease."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11481-010-9193-z"xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Ren Z."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Tao D."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Goswami R."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Balabanov R."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Liebenson D."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Liggett T."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/author | "Stefoski D."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/name | "J Neuroimmune Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/pages | "260-265"xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/title | "Central nervous system expression of interferon regulatory factor 1 regulates experimental autoimmune encephalomyelitis."xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20177805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20177805 |
| http://purl.uniprot.org/citations/20177805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20177805 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK53-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK11-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |
| http://purl.uniprot.org/uniprot/#_A0A1B1RS94-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |
| http://purl.uniprot.org/uniprot/#_A0A510GDD8-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |
| http://purl.uniprot.org/uniprot/#_B4DQF0-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |
| http://purl.uniprot.org/uniprot/#_P10914-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |
| http://purl.uniprot.org/uniprot/#_Q59F37-mappedCitation-20177805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20177805 |