http://purl.uniprot.org/citations/20178747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20178747 | http://www.w3.org/2000/01/rdf-schema#comment | "Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2010.01.027"xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Gronostajski R.M."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Cossu G."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Magli A."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Messina G."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Grossi M."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Campbell C.E."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Goldhamer D.J."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Tagliafico E."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Monteverde S."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Perani L."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Biressi S."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Roncaglia E."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Cassano M."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/author | "Starnes L."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/pages | "554-566"xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/title | "Nfix regulates fetal-specific transcription in developing skeletal muscle."xsd:string |
http://purl.uniprot.org/citations/20178747 | http://purl.uniprot.org/core/volume | "140"xsd:string |
http://purl.uniprot.org/citations/20178747 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20178747 |
http://purl.uniprot.org/citations/20178747 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20178747 |
http://purl.uniprot.org/uniprot/#_A0A0J9YKD4-mappedCitation-20178747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20178747 |