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http://purl.uniprot.org/citations/20178747http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20178747http://www.w3.org/2000/01/rdf-schema#comment"Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryonic genes such as slow myosin. In the case of the MCK promoter, Nfix forms a complex with PKC theta that binds, phosphorylates, and activates MEF2A. Premature expression of Nfix activates fetal and suppresses embryonic genes in embryonic muscle, whereas muscle-specific ablation of Nfix prevents fetal and maintains embryonic gene expression in the fetus. Therefore, Nfix acts as a transcriptional switch from embryonic to fetal myogenesis."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.org/dc/terms/identifier"doi:10.1016/j.cell.2010.01.027"xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Gronostajski R.M."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Cossu G."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Magli A."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Messina G."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Grossi M."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Campbell C.E."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Goldhamer D.J."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Tagliafico E."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Monteverde S."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Perani L."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Biressi S."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Roncaglia E."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Cassano M."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/author"Starnes L."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/pages"554-566"xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/title"Nfix regulates fetal-specific transcription in developing skeletal muscle."xsd:string
http://purl.uniprot.org/citations/20178747http://purl.uniprot.org/core/volume"140"xsd:string
http://purl.uniprot.org/citations/20178747http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20178747
http://purl.uniprot.org/citations/20178747http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20178747
http://purl.uniprot.org/uniprot/#_A0A0J9YKD4-mappedCitation-20178747http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20178747