| http://purl.uniprot.org/citations/20178780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20178780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20178780 | http://www.w3.org/2000/01/rdf-schema#comment | "During vesicular transport between the endoplasmic reticulum and the Golgi, members of the TMED/p24 protein family form hetero-oligomeric complexes that facilitate protein-cargo recognition as well as vesicle budding. In addition, they regulate each other's level of expression. Despite analyses of TMED/p24 protein distribution in mammalian cells, yeast, and C. elegans, little is known about the role of this family in vertebrate embryogenesis. We report the presence of a single point mutation in Tmed2/p24beta(1) in a mutant mouse line, 99J, identified in an ENU mutagenesis screen for recessive developmental abnormalities. This mutation does not affect Tmed2/p24beta(1) mRNA levels but results in loss of TMED2/p24beta(1) protein. Prior to death at mid-gestation, 99J homozygous mutant embryos exhibit developmental delay, abnormal rostral-caudal elongation, randomized heart looping, and absence of the labyrinth layer of the placenta. We find that Tmed2/p24beta(1) is normally expressed in tissues showing morphological defects in 99J mutant embryos and that these affected tissues lack the TMED2/p24beta(1) oligomerization partners, TMED7/p24gamma(3) and TMED10/p24delta(1). Our data reveal a requirement for TMED2/p24beta(1) protein in the morphogenesis of the mouse embryo and placenta."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.02.019"xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.02.019"xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Lupu F."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Lupu F."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Lacy E."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Lacy E."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Jerome-Majewska L.A."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Jerome-Majewska L.A."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Achkar T."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/author | "Achkar T."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/pages | "154-166"xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/pages | "154-166"xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/title | "The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/title | "The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta."xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/volume | "341"xsd:string |
| http://purl.uniprot.org/citations/20178780 | http://purl.uniprot.org/core/volume | "341"xsd:string |