| http://purl.uniprot.org/citations/20185691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20185691 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from enteroendocrine K cells in response to meals. Posttranslational processing of the precursor protein pro-GIP at residue 65 by proprotein convertase subtilisin/kexin type 1 (PC1/3) in gut K cells gives rise to the established 42-amino-acid form of GIP (GIP(1-42)). However, the pro-GIP peptide sequence contains a consensus cleavage site for PC2 at residues 52-55 and we identified PC2 immunoreactivity in a subset of K cells, suggesting the potential existence of a COOH-terminal truncated GIP isoform, GIP(1-30). Indeed a subset of mouse and human K cells display GIP immunoreactivity with GIP antibodies directed to the mid portion of the peptide, but not with a COOH-terminal-directed GIP antibody, indicative of the presence of a truncated form of GIP. This population of cells represents approximately 5-15% of the total GIP-immunoreactive cells in mice, depending on the region of intestine, and is virtually absent in mice lacking PC2. Amidated GIP(1-30) and GIP(1-42) have comparable potency at stimulating somatostatin release in the perfused mouse stomach. Therefore, GIP(1-30) represents a naturally occurring, biologically active form of GIP."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.00024.2010"xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/author | "Kwok Y.N."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/author | "Asadi A."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/author | "Kieffer T.J."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/author | "Yang G.K."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/pages | "G608-14"xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/title | "Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut."xsd:string |
| http://purl.uniprot.org/citations/20185691 | http://purl.uniprot.org/core/volume | "298"xsd:string |
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