| http://purl.uniprot.org/citations/20185831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20185831 | http://www.w3.org/2000/01/rdf-schema#comment | "Erk-5, a member of the MAPK superfamily, has a catalytic domain similar to Erk1/2 and a unique C-terminal domain enabling binding with transcription factors. Aberrant vascularization in the Erk5-null mice suggested a link to angiogenesis. Ectopic expression of constitutively active Erk5 blocks endothelial cell morphogenesis and causes HIF1-alpha destabilization/degradation. However the mechanisms by which endogenous Erk5 regulates angiogenesis remain unknown. We show that Erk5 and its activating kinase MEK5 are the upstream mediators of the anti-angiogenic signal by the natural angiogenesis inhibitor, pigment epithelial-derived factor (PEDF). We demonstrate that Erk5 phosphorylation allows activation of PPARgamma transcription factor by displacement of SMRT co-repressor. PPARgamma, in turn is critical for NFkappaB activation, PEDF-dependent apoptosis, and anti-angiogenesis. The dominant negative MEK5 mutant and Erk5 shRNA diminished PEDF-dependent apoptosis, inhibition of the endothelial cell chemotaxis, and angiogenesis. This is the first evidence of Erk5-dependent transduction of signals by endogenous angiogenesis inhibitors."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.117374"xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/author | "Kwiatek A."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/author | "Volpert O.V."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/author | "Veliceasa D."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/author | "Cohen R.N."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/author | "Biyashev D."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/author | "Sutanto M.M."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/pages | "13517-13524"xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/title | "Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma)."xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20185831 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20185831 |
| http://purl.uniprot.org/citations/20185831 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20185831 |
| http://purl.uniprot.org/uniprot/#_D0EPX6-mappedCitation-20185831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20185831 |
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| http://purl.uniprot.org/uniprot/#_P37238-mappedCitation-20185831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20185831 |
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| http://purl.uniprot.org/uniprot/#_P97298-mappedCitation-20185831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20185831 |
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