| http://purl.uniprot.org/citations/20193031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20193031 | http://www.w3.org/2000/01/rdf-schema#comment | "Natural killer (NK) cells eliminate infected and transformed cells while still are self-tolerant. Interactions of the independently segregating Killer cell immunoglobulin-like receptors (KIR) and human leucocyte antigens (HLA) loci play a critical role in NK cell regulation. Different compound KIR-HLA genotypes can impart different thresholds of activation to the NK-cell repertoire and such genotypic variation has been found to confer altered risk in a number of human diseases including viral infections, autoimmune disorders, reproduction abnormalities and cancers. In this study, we presented a novel combined KIR-HLA polymerase chain reaction-sequence-specific primers genotyping assay for simultaneous determination of KIR genes and their three major HLA class I ligand groups (C1, C2, and Bw4). Moreover, known inhibitory and activating KIR + HLA (iKIR + HLA: 2DL2/3 + C1, 2DL1 + C2, 3DL1 + Bw4; and aKIR + HLA: 2DS2 + C1, 2DS1 + C2, 3DS1 + Bw4) combinations as well as co-inheritance of aKIR genes and iKIR + HLA pairs were analysed in a total of 200 unrelated healthy Iranian individuals. All tested subjects had at least one of the three iKIR + HLA pairs and the frequencies of various inhibitory combinations in the study group were: 31.5%, three iKIR + HLA pairs, 53.5%, two iKIR + HLA pairs, and 15%, 0ne iKIR + HLA pair. Furthermore, we revealed that majority of Iranians (69%) carry compound genotypes with greater number of inhibitory pairings than activating combinations (iKIR + HLA > aKIR + HLA). Conversely, iKIR + HLA < aKIR (45%) was dominant genotype in the study group. We conclude that selective evolutionary pressure has propensity to maintain KIR-HLA genotypes with more inhibitory combinations to guarantee self-tolerance. In contrast, existence of activating KIR genes without normal endogenous ligands, potentially arms the NK population for competent immunosurveillance and stronger defense against infections."xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1744-313x.2010.00906.x"xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/author | "Nasiri M."xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/author | "Tajik N."xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/author | "Radjabzadeh M.F."xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/author | "Shahsavar F."xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/name | "Int J Immunogenet"xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/pages | "159-168"xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/title | "Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay."xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/20193031 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20193031 |
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