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http://purl.uniprot.org/citations/20193456http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20193456http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the polymorphism of HLA-DRB1 and DQB1 allele in esophageal squamous cell carcinomas of Kazakh in Xinjiang, and to characterize susceptible genes for the family of Kazakh esophageal squamous cell carcinoma.

Methods

HLA-DRB1*0901, DRB1*1501, DQB1*0301, DQB1*0602 alleles were genotyped by sequence specific primers using polymerase chain reaction (PCR-SSP) in 200 Kazakh esophageal squamous cell carcinoma and 177 normal esophageal mucosa.

Results

The frequency of HLA-DRB1*1501, HLA-DQB1*0301, HLA-DQB1*0602 alleles in 200 Kazakh esophageal squamous cell carcinoma (0.455, 0.760 and 0.690) were significantly higher than that of 177 normal esophageal mucosa (0.232, 0.520, 0.554; OR = 2.78, 2.93, 1.80; P < 0.05). The frequency of HLA-DRB1*0901 between the carcinoma (0.105) and control groups (0.102) had no association (OR = 1.036, P > 0.05); The frequency of HLA-DQB1*0602 was higher in poor-differentiated squamous cell carcinomas (0.742) than that of well-differentiated tumors (0.597, P < 0.05).

Conclusions

HLA-DRB1*1501, HLA-DQB1*0301, HLA-DQB1* 0602 may be susceptible to Kazakh esophageal squamous cell carcinoma. HLA-DQB1*0602 correlates with well-differentiated esophageal squamous cell carcinoma."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Li F."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Qi Y."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Yang L."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Liu C.X."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Yin L."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Liang W.H."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Chen Y.Z."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Hu J.M."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Jiang J.F."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Li W.T."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/author"Li H.A."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/name"Zhonghua Bing Li Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/pages"816-819"xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/title"[Correlation between HLA-DRB1*0901 and 1501, HLA-DQB1*0301 and 0602 alleles and esophageal squamous cell carcinoma of Kazakh in Xinjiang, China]."xsd:string
http://purl.uniprot.org/citations/20193456http://purl.uniprot.org/core/volume"38"xsd:string
http://purl.uniprot.org/citations/20193456http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20193456
http://purl.uniprot.org/citations/20193456http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20193456
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-20193456http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20193456
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-20193456http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20193456
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