| http://purl.uniprot.org/citations/20195543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20195543 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundDefensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce alpha-defensins1-3 and that alpha-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of alpha-defensins1-3 production by DC on disease progression.Methodology/principal findingsMonocyte-derived DC (MDDC) were analyzed comparatively in healthy controls (HC) and HIV-infected patients, including untreated "elite" and "viremic" controllers, untreated viremic non-controllers and antiretroviral-treated patients. We found that production of alpha-defensins1-3 was significantly increased in MDDC from HIV-infected patients versus HC, and this increase was mainly due to that observed in controllers, while in non-controllers the increase was not statistically significant (controllers vs. HC, p<0.005; controllers vs. non-controllers p<0.05). Secreted alpha-defensins1-3 by immature MDDC positively correlated with CD4 T cell counts in controllers, but not in non-controllers. Moreover, independently of their clinical classification, HIV-infected patients with higher alpha-defensins1-3 secretion by immature MDDC showed slower disease progression, measured as no decrease in the number of CD4+ T-cells below 350 cell/mm(3), lower increase of plasma viral load and no initiation of treatment over time. Plasma alpha-defensins1-3 levels lacked any relationship with immunologic and virologic parameters.Conclusions/significanceHigh production of alpha-defensins1-3 by immature DCs appears as a host protective factor against progression of HIV-1 infection, suggesting potential diagnostic, therapeutic and preventive implications. This protective effect may arise from the activity of alpha-defensins1-3 to damage the virions prior and/or after their internalization by immature DC, and hence favoring a more efficient viral processing and presentation to HIV-specific CD4+ T cells, without or with a minor rate of transmission of infectious HIV-1 virions."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0009436"xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Franco R."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Casanova V."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Climent N."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Gallart T."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Garcia F."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Gatell J.M."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Rodriguez-Garcia M."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Leon A."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/author | "Oliva H."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/pages | "e9436"xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/title | "Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression."xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20195543 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20195543 |
| http://purl.uniprot.org/citations/20195543 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20195543 |
| http://purl.uniprot.org/uniprot/#_Q6EZE9-mappedCitation-20195543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20195543 |
| http://purl.uniprot.org/uniprot/#_P59665-mappedCitation-20195543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20195543 |
| http://purl.uniprot.org/uniprot/#_P59666-mappedCitation-20195543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20195543 |
| http://purl.uniprot.org/uniprot/P59666 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20195543 |
| http://purl.uniprot.org/uniprot/Q6EZE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20195543 |
| http://purl.uniprot.org/uniprot/P59665 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20195543 |