| http://purl.uniprot.org/citations/20200162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20200162 | http://www.w3.org/2000/01/rdf-schema#comment | "G(q)-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of different cellular functions. These receptors can regulate a highly interconnected network of biochemical routes that control the activity of several members of the mitogen-activated protein kinase (MAPK) family. The ERK5 MAPK has been shown to be activated by G(q)-coupled GPCR via unknown mechanisms. We find that the atypical protein kinase C (PKCzeta), previously reported to interact with the ERK5 activator MEK5 and to be involved in epidermal growth factor-mediated ERK5 stimulation, plays a crucial role in the activation of the ERK5 pathway by G(q)-coupled GPCR. Stimulation of ERK5 by G(q)-coupled GPCR is abolished upon pharmacological inhibition of PKCzeta as well as in embryonic fibroblasts obtained from PKCzeta-deficient mice. Both PKCzeta and MEK5 associate to G alpha(q) upon activation of GPCR, thus forming a ternary complex that seems essential for the activation of ERK5. These data put forward a novel function of G alpha(q) as a scaffold protein involved in the modulation of the ERK5 cascade by GPCR that could be relevant in G(q)-mediated physiological functions."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.098699"xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/author | "Diaz-Meco M.T."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/author | "Moscat J."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/author | "Ribas C."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/author | "Mayor F."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/author | "Garcia-Hoz C."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/author | "Sanchez-Fernandez G."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/pages | "13480-13489"xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/title | "G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR)."xsd:string |
| http://purl.uniprot.org/citations/20200162 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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