| http://purl.uniprot.org/citations/20201036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20201036 | http://www.w3.org/2000/01/rdf-schema#comment | "P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel within the multiprotein inflammasome complex. Until now, little is known about regulation of P2X7 effector functions in macrophages. In this study, we show that nucleoside triphosphate diphosphohydrolase 1 (NTPDase1)/CD39 is the dominant ectonucleotidase expressed by murine peritoneal macrophages and that it regulates P2X7-dependent responses in these cells. Macrophages isolated from NTPDase1-null mice (Entpd1(-/-)) were devoid of all ADPase and most ATPase activities when compared with WT macrophages (Entpd1(+/+)). Entpd1(-/-) macrophages exposed to millimolar concentrations of ATP were more susceptible to cell death, released more IL-1beta and IL-18 after TLR2 or TLR4 priming, and incorporated the fluorescent dye Yo-Pro-1 more efficiently (suggestive of increased pore formation) than Entpd1(+/+) cells. Consistent with these observations, NTPDase1 regulated P2X7-associated IL-1beta release after synthesis, and this process occurred independently of, and prior to, cytokine maturation by caspase-1. NTPDase1 also inhibited IL-1beta release in vivo in the air pouch inflammatory model. Exudates of LPS-injected Entpd1(-/-) mice had significantly higher IL-1beta levels when compared with Entpd1(+/+) mice. Altogether, our studies suggest that NTPDase1/CD39 plays a key role in the control of P2X7-dependent macrophage responses."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200939741"xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/author | "Enjyoji K."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/author | "Robson S.C."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/author | "Kukulski F."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/author | "Levesque S.A."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/author | "Sevigny J."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/pages | "1473-1485"xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/title | "NTPDase1 governs P2X7-dependent functions in murine macrophages."xsd:string |
| http://purl.uniprot.org/citations/20201036 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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