| http://purl.uniprot.org/citations/20208530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20208530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20208530 | http://www.w3.org/2000/01/rdf-schema#comment | "Several subunits of the class III phosphatidylinositol-3-OH kinase (PI(3)K-III) complex are known as tumour suppressors. Here we uncover a function for this complex and its catalytic product phosphatidylinositol-3-phosphate (PtdIns(3)P) in cytokinesis. We show that PtdIns(3)P localizes to the midbody during cytokinesis and recruits a centrosomal protein, FYVE-CENT (ZFYVE26), and its binding partner TTC19, which in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis. Translocation of FYVE-CENT and TTC19 from the centrosome to the midbody requires another FYVE-CENT-interacting protein, the microtubule motor KIF13A. Depletion of the VPS34 or Beclin 1 subunits of PI(3)K-III causes cytokinesis arrest and an increased number of binucleate and multinucleate cells, in a similar manner to the depletion of FYVE-CENT, KIF13A or TTC19. These results provide a mechanism for the translocation and docking of a cytokinesis regulatory machinery at the midbody."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2036"xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2036"xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Poulton J."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Poulton J."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Raiborg C."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Raiborg C."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Nezis I.P."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Nezis I.P."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Rusten T.E."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Rusten T.E."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Sagona A.P."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Sagona A.P."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Liestol K."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Liestol K."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Pedersen N.M."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Pedersen N.M."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Skotheim R.I."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/author | "Skotheim R.I."xsd:string |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20208530 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |