| http://purl.uniprot.org/citations/20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20209134 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundMHC-II restricted CD4+ T cells are dependent on antigen presenting cells (APC) for their activation. APC dysfunction in HIV-infected individuals could accelerate or exacerbate CD4+ T cell dysfunction and may contribute to increased levels of immunodeficiency seen in some patients regardless of their CD4+ T cell numbers. Here we test the hypothesis that APC from HIV-infected individuals have diminished antigen processing and presentation capacity.Methodology/principal findingsMonocytes (MN) were purified by immuno-magnetic bead isolation techniques from HLA-DR1.01+ or DR15.01+ HIV-infected and uninfected individuals. MN were analyzed for surface MHC-II expression and for antigen processing and presentation capacity after overnight incubation with soluble antigen or peptide and HLA-DR matched T cell hybridomas. Surface expression of HLA-DR was 20% reduced (p<0.03) on MN from HIV-infected individuals. In spite of this, there was no significant difference in antigen processing and presentation by MN from 14 HIV-infected donors (8 HLA-DR1.01+ and 6 HLA-DR15.01+) compared to 24 HIV-uninfected HLA-matched subjects.Conclusions/significanceWe demonstrated that MHC class II antigen processing and presentation is preserved in MN from HIV-infected individuals. This further supports the concept that this aspect of APC function does not further contribute to CD4+ T cell dysfunction in HIV disease."xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0009491"xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/author | "Canaday D.H."xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/author | "Ramachandra L."xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/author | "Smultea L."xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/author | "Woc-Colburn L."xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/pages | "e9491"xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/title | "Preserved MHC class II antigen processing in monocytes from HIV-infected individuals."xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/20209134 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20209134 |
| http://purl.uniprot.org/citations/20209134 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WB88-mappedCitation-20209134 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20209134 |