| http://purl.uniprot.org/citations/20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20211980 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies have proposed a role for neuromedin B (NB), a bombesin-like peptide, in the control of body weight homeostasis. However, the nature of this role is unclear. The actions of NB are mediated preferentially by NB-preferring receptors (NBRs). Here we examined the consequences of targeted deletion of NBRs in female mice on body weight homeostasis in mice fed a normolipid diet (ND) or a high-fat diet (HFD) for 13 weeks. Body weight and food ingestion of neuromedin B receptor knockout (NBR-KO) mice fed a normolipid diet showed no difference in relation to wild-type (WT). However, the high-fat diet induced an 8.9- and 4.8-fold increase in body weight of WT and NBR-KO, respectively, compared to their controls maintained with a normolipid diet, even though the mice ingested the same amount of calories, regardless of genotype. Comparing mice fed the high-fat diet, NBR-KO mice accumulated approximately 45% less fat depot mass than WT, exhibited a lower percentage of fat in their carcasses (19.2 vs. 31.3%), and their adipocytes were less hypertrophied. Serum leptin and leptin mRNA in inguinal and perigonadal fat were lower in HFD NBR-KO than HFD WT, and serum adiponectin was similar among HFD groups and unaltered in comparison to ND-fed mice. HFD-fed WT mice developed glucose intolerance but not the HFD-fed NBR-KO mice, although they had similar glycaemia and insulinaemia. NBR-KO and WT mice on the normolipid diet showed no differences in any parameters, except for a trend to lower insulin levels. Therefore, disruption of the neuromedin B receptor pathway did not change body weight homeostasis in female mice fed a normolipid diet; however, it did result in partial resistance to diet-induced obesity."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.org/dc/terms/identifier | "doi:10.1113/jphysiol.2009.185322"xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Wada E."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Pazos-Moura C.C."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Ortiga-Carvalho T.M."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Oliveira K.J."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Souza L.L."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Cabanelas A."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Bloise F.F."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Mello-Coelho V."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/author | "Paula G.S."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/name | "J Physiol"xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/pages | "1635-1645"xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/title | "Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity."xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://purl.uniprot.org/core/volume | "588"xsd:string |
| http://purl.uniprot.org/citations/20211980 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20211980 |
| http://purl.uniprot.org/citations/20211980 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20211980 |
| http://purl.uniprot.org/uniprot/#_A0A087WQJ7-mappedCitation-20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20211980 |
| http://purl.uniprot.org/uniprot/#_A0A087WP36-mappedCitation-20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20211980 |
| http://purl.uniprot.org/uniprot/#_A0A087WPA3-mappedCitation-20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20211980 |
| http://purl.uniprot.org/uniprot/#_A0A087WRS7-mappedCitation-20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20211980 |
| http://purl.uniprot.org/uniprot/#_O54799-mappedCitation-20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20211980 |
| http://purl.uniprot.org/uniprot/#_Q0VEH1-mappedCitation-20211980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20211980 |