| http://purl.uniprot.org/citations/20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20213747 | http://www.w3.org/2000/01/rdf-schema#comment | "DJ-1 has been reported as a gene linked to early onset familial Parkinson's disease, and is functionally involved in transcriptional regulation and oxidative stress-induced cell death. To understand the role of DJ-1 in cellular stress, this study investigated DJ-1's effect on stress-activated protein kinase signaling and H(2)O(2)-induced activation of apoptosis signal-regulating kinase 1 (ASK1). According to the results, the overexpression of DJ-1 inhibited H(2)O(2)-induced activation of ASK1 as well as the activation of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade. The results of both in vivo binding and kinase studies have revealed that ASK1 is the direct target of DJ-1, whereas it has shown no effect on either MKK3 or p38. DJ-1 blocked both the homo-oligomerization of ASK1 and inhibited ASK1 activity. Taken together, our data strongly suggest that DJ-1, by directly inhibiting ASK1, may act as a negative regulator in ASK1 signaling cascades."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22530"xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Choi Y.H."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Seo M.S."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Park H.S."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Yoon J.H."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Kim M.Y."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Hong J.A."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Ann E.J."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/author | "Mo J.S."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/pages | "229-237"xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/title | "DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1."xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/20213747 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20213747 |
| http://purl.uniprot.org/citations/20213747 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20213747 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TMH5-mappedCitation-20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20213747 |
| http://purl.uniprot.org/uniprot/#_A0A510GDE6-mappedCitation-20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20213747 |
| http://purl.uniprot.org/uniprot/#_B4DF67-mappedCitation-20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20213747 |
| http://purl.uniprot.org/uniprot/#_B4E0K5-mappedCitation-20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20213747 |
| http://purl.uniprot.org/uniprot/#_B5TY33-mappedCitation-20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20213747 |
| http://purl.uniprot.org/uniprot/#_Q15454-mappedCitation-20213747 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20213747 |