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| http://purl.uniprot.org/citations/20215404 | http://www.w3.org/2000/01/rdf-schema#comment | "Organization of the plasma membrane in polarized epithelial cells is accomplished by the specific localization of transmembrane or membrane-associated proteins, which are often linked to cytoplasmic protein complexes, including the actin cytoskeleton. In this study, we identified Sip1 as a Drosophila orthologue of the ezrin-radixin-moesin (ERM) binding protein 50 (EBP50; also known as the Na(+)/H(+) exchanger regulatory factor NHERF1). In mammals, EBP50/NHERF1 is a scaffold protein required for the regulation of several transmembrane receptors and downstream signal transduction activity. In Drosophila, loss of Sip1 leads to a reduction in Slik kinase protein abundance, loss of Moesin phosphorylation and changes in epithelial structure, including mislocalization of E-cadherin and F-actin. Consistent with these findings, Moesin and Sip1 act synergistically in genetic-interaction experiments, and Sip1 protein abundance is dependent on Moesin. Co-immunoprecipitation experiments indicate that Sip1 forms a complex with both Moesin and Slik. Taken together, these data suggest that Sip1 promotes Slik-dependent phosphorylation of Moesin, and suggests a mechanism for the regulation of Moesin activity within the cell to maintain epithelial integrity."xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.059469"xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/author | "Fehon R.G."xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/author | "Hughes S.C."xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/pages | "1099-1107"xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/title | "Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity."xsd:string |
| http://purl.uniprot.org/citations/20215404 | http://purl.uniprot.org/core/volume | "123"xsd:string |
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