| http://purl.uniprot.org/citations/20219973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20219973 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast SBF transcription factor is a heterodimer comprised of Swi4 and Swi6 that has a well defined role in cell cycle-specific transcription. SBF serves a second function in the transcriptional response to cell wall stress in which activated Mpk1 mitogen-activated protein kinase of the cell wall integrity signaling pathway forms a complex with Swi4, the DNA binding subunit of SBF, conferring upon Swi4 the ability to bind DNA and activate transcription of FKS2. Although Mpk1-Swi4 complex formation and transcriptional activation of FKS2 does not require Mpk1 catalytic activity, Swi6 is phosphorylated by Mpk1 and must be present in the Mpk1-Swi4 complex for transcriptional activation of FKS2. Here, we find that Mpk1 regulates Swi6 nucleocytoplasmic shuttling in a biphasic manner. First, formation of the Mpk1-Swi4 complex recruits Swi6 to the nucleus for transcriptional activation. Second, Mpk1 negatively regulates Swi6 by phosphorylation on Ser238, which inhibits nuclear entry. Ser238 neighbors a nuclear localization signal (NLS) whose function is blocked by phosphorylation at Ser238 in a manner similar to the regulation by Cdc28 of another Swi6 NLS, revealing a mechanism for the integration of multiple signals to a single endpoint. Finally, the Kap120 beta-importin binds the Mpk1-regulated Swi6 NLS but not the Cdc28-regulated NLS."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e09-11-0923"xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/author | "Kim K.Y."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/author | "Truman A.W."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/author | "Schlenstedt G."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/author | "Levin D.E."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/author | "Caesar S."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/pages | "1609-1619"xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/title | "Yeast Mpk1 cell wall integrity mitogen-activated protein kinase regulates nucleocytoplasmic shuttling of the Swi6 transcriptional regulator."xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/20219973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20219973 |
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