| http://purl.uniprot.org/citations/20224733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20224733 | http://www.w3.org/2000/01/rdf-schema#comment | "The E2F family of transcription factors play a critical role in the control of cell proliferation. E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. E2F-1-mediated activation and repression of target genes occurs in different settings. The role of E2F-1 and E2F-1/pRB complexes in regulation of different target genes, and in cycling versus quiescent cells, is unclear. In this study, effects of free E2F-1 (doesn't complex with pRb) and E2F-1/pRb complex, on E2F-1 target gene expression were compared in different cell growth conditions. Findings suggest that E2F-1 acts in different ways, not only depending on the target gene but also depending on different stages of the cell cycle. For example, E2F-1 acts as part of the repression complex with pRB in the expression of DHFR, b-myb, TK and cdc2 in asynchronously growing cells; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle."xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.org/dc/terms/identifier | "doi:10.7150/ijbs.6.116"xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/author | "Sahin F."xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/author | "Sladek T.L."xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/name | "Int J Biol Sci"xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/pages | "116-128"xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/title | "E2F-1 has dual roles depending on the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/20224733 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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