| http://purl.uniprot.org/citations/20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20226669 | http://www.w3.org/2000/01/rdf-schema#comment | "The internalization of transmembrane receptors from the cell surface plays a central role in signal regulation. Receptor internalization can occur through different routes; however, because of the difficulty in selectively blocking these routes in vivo, their roles in signaling are poorly understood. Here we use null mutations in Drosophila dynamin, clathrin, and AP-2 adaptor subunits to analyze internalization requirements for the Delta ligand and its receptor, Notch. Bulk Notch is internalized via AP-2-dependent endocytosis, but signaling by Notch requires AP-2-independent clathrin-dependent endocytosis, highlighting a distinction between Notch endocytic routes required for degradation versus signaling activation. Signaling by Delta requires dynamin, but whether this generates a pulling force of Delta on Notch or allows for Delta entry into a recycling pathway to gain signaling competence is widely debated. Surprisingly, we show that signaling by Delta in germline cells can occur by clathrin-independent endocytosis, when endosomal entry is blocked, and when activity of Rab11 or its effectors is reduced, suggesting that Delta need not pass through a recognized recycling pathway to achieve signaling competence. The absolute requirement for dynamin-dependent endocytosis but not endosomal entry or Rab11 activity supports "pulling force" rather than "recycling" models for Delta activation."xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2010.01.049"xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/author | "Bilder D."xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/author | "Windler S.L."xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/pages | "538-543"xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/title | "Endocytic internalization routes required for delta/notch signaling."xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/20226669 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20226669 |
| http://purl.uniprot.org/citations/20226669 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20226669 |
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| http://purl.uniprot.org/uniprot/P29742#attribution-60168C7D72AF8FD8DA45CCFA27349E28 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/P27619#attribution-60168C7D72AF8FD8DA45CCFA27349E28 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/Q9VS85#attribution-60168C7D72AF8FD8DA45CCFA27349E28 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/Q9VDC3#attribution-60168C7D72AF8FD8DA45CCFA27349E28 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/O62530#attribution-60168C7D72AF8FD8DA45CCFA27349E28 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20226669 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4JDA7-mappedCitation-20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCU7-mappedCitation-20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD53-mappedCitation-20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7H5-mappedCitation-20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/#_A4V4I8-mappedCitation-20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20226669 |
| http://purl.uniprot.org/uniprot/#_A4V4J0-mappedCitation-20226669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20226669 |