| http://purl.uniprot.org/citations/20227367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20227367 | http://www.w3.org/2000/01/rdf-schema#comment | "To sustain tumor growth, cancer cells must be able to adapt to fluctuations in energy availability. We have identified a single microRNA that controls glioma cell proliferation, migration, and responsiveness to glucose deprivation. Abundant glucose allows relatively high miR-451 expression, promoting cell growth. In low glucose, miR-451 levels decrease, slowing proliferation but enhancing migration and survival. This allows cells to survive metabolic stress and seek out favorable growth conditions. In glioblastoma patients, elevated miR-451 is associated with shorter survival. The effects of miR-451 are mediated by LKB1, which it represses through targeting its binding partner, CAB39 (MO25 alpha). Overexpression of miR-451 sensitized cells to glucose deprivation, suggesting that its downregulation is necessary for robust activation of LKB1 in response to metabolic stress. Thus, miR-451 is a regulator of the LKB1/AMPK pathway, and this may represent a fundamental mechanism that contributes to cellular adaptation in response to altered energy availability."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.02.018"xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Ostrowski M.C."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Bronisz A."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Godlewski J."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Chiocca E.A."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Nowicki M.O."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Nuovo G."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Palatini J."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "De Lay M."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Lawler S.E."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/author | "Van Brocklyn J."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/pages | "620-632"xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/title | "MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells."xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/20227367 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20227367 |
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| http://purl.uniprot.org/uniprot/#_Q15831-mappedCitation-20227367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20227367 |