| http://purl.uniprot.org/citations/20228063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20228063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20228063 | http://www.w3.org/2000/01/rdf-schema#comment | "C53/LZAP (also named as Cdk5rap3) is a putative tumor suppressor that plays important roles in multiple cell signaling pathways, including DNA damage response and NF-kappaB signaling. Yet how its function is regulated remains largely unclear. Here we report the isolation and characterization of two novel C53/LZAP-interacting proteins, RCAD (Regulator of C53/LZAP and DDRGK1) and DDRGK1 (DDRGK domain-containing protein 1). Our co-immunoprecipitation assays confirmed their interactions, while gel filtration assay indicated that C53/LZAP and RCAD may form a large protein complex. Intriguingly, we found that RCAD knockdown led to dramatic reduction of C53/LZAP and DDRGK1 proteins. We also found that C53/LZAP and DDRGK1 became more susceptible to the proteasome-mediated degradation in RCAD knockdown cells, whereas their ubiquitination was significantly attenuated by RCAD overexpression. In addition, we found that RCAD, like C53/LZAP, also plays an important role in regulation of NF-kappaB signaling and cell invasion. Taken together, our findings strongly suggest that RCAD is a novel regulator of C53/LZAP tumor suppressor and NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.110619"xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.110619"xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Mei M."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Mei M."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Lei G."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/author | "Lei G."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/pages | "15126-15136"xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/pages | "15126-15136"xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/title | "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/title | "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling."xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20228063 | http://purl.uniprot.org/core/volume | "285"xsd:string |