| http://purl.uniprot.org/citations/20231359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20231359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20231359 | http://www.w3.org/2000/01/rdf-schema#comment | "Mpv17-like protein (M-LP) is a protein that has been suggested to be involved in the metabolism of reactive oxygen species. The two M-LP isoforms in mouse, M-LP(S) and M-LP(L), are generated by the alternative usage of promoters. M-LP(S) is expressed exclusively in kidneys after the age of 6 weeks, whereas M-LP(L) is expressed ubiquitously. To elucidate the molecular basis of M-LP(S) expression, we searched for cis-regulatory elements in the promoter region of M-LP(S) and identified heat shock element half-sites as positive elements and a Tramtrack 69K (Ttk 69K) binding site as a negative element. Furthermore, we isolated a novel transcription repressor, Rhit (regulator of heat-induced transcription), that binds to the Ttk 69K binding site within the M-LP(S) promoter by DNA affinity chromatography and confirmed its participation in the transcriptional regulation of M-LP(S) by RNA interference (RNAi). Sequence analysis revealed that Rhit contains a KRAB (Krüppel-associated box) domain and a DNA-binding domain composed of eight C(2)H(2)-type zinc fingers. Interestingly, exposure to heat shock stress resulted in the upregulation of M-LP(S) expression concurrent with the downregulation of Rhit expression. Moreover, the age-dependent expression of M-LP(S) was inversely correlated with that of Rhit. These observations strongly suggest that Rhit acts as a repressor in the heat-induced and age-dependent transcriptional regulation of M-LP(S)."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01025-09"xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01025-09"xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/author | "Yasuda T."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/author | "Ueki M."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/author | "Ueki M."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/author | "Iida R."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/author | "Iida R."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/pages | "2306-2315"xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/pages | "2306-2315"xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/title | "A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/title | "A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism."xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20231359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20231359 |
| http://purl.uniprot.org/citations/20231359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20231359 |
| http://purl.uniprot.org/citations/20231359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20231359 |
| http://purl.uniprot.org/citations/20231359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20231359 |