| http://purl.uniprot.org/citations/20299238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20299238 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionMonocyte chemoattractant protein-1 (MCP-1) is elevated after acute myocardial infarction (AMI), and potentiates left ventricular (LV) remodeling in murine models of AMI. We examined the relationships between serum MCP-1, change in LV function and biomarkers related to remodeling in a cohort of AMI patients.MethodsSerum MCP-1 concentrations were measured in 100 patients (age 58.9+/-12.0 years, 77% male) admitted with AMI and LV dysfunction, at baseline (mean 46 h), 12 and 24 weeks; cardiac magnetic resonance imaging and measurement of matrix metalloproteinase-2 (MMP-2), MMP-3 and MMP-9 occurred at each time-point.ResultsMCP-1 increased significantly from 697 [483, 997]pg/mL at baseline to 878 [678, 1130]pg/mL at 24 weeks (p<0.001). MMP-3 concentration increased while MMP-9 decreased significantly over time; MMP-2 concentration did not change significantly. BASELINE MCP-1 correlated with change in (Delta) LV end-systolic volume index (DeltaLVESVI; r= -0.48, p=0.01) and with DeltaLV ejection fraction (DeltaLVEF; r=0.50, p=0.02). However, DeltaMCP-1 correlated positively with DeltaLVESVI (r=0.40, p=0.006) and negatively with DeltaLVEF (r= -0.36, p=0.004). MCP-1 had no relationship with any MMP.ConclusionsMCP-1 may have a dichotomous role following AMI, aiding early infarct healing but potentiating later remodeling, which merits further study before any therapeutic trials of MCP-1 modulation in humans."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2010.02.020"xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Murphy C.A."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Dargie H.J."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "McMurray J.J."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Clements S."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Martin T.N."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Steedman T."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Petrie C.J."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Wagner G.S."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/author | "Weir R.A."xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/pages | "158-162"xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/title | "Monocyte chemoattractant protein-1: a dichotomous role in cardiac remodeling following acute myocardial infarction in man?"xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/20299238 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20299238 |
| http://purl.uniprot.org/citations/20299238 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20299238 |
| http://purl.uniprot.org/uniprot/#_J3KRT7-mappedCitation-20299238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299238 |
| http://purl.uniprot.org/uniprot/#_P13500-mappedCitation-20299238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299238 |
| http://purl.uniprot.org/uniprot/#_Q6UZ82-mappedCitation-20299238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299238 |
| http://purl.uniprot.org/uniprot/#_V9GZU2-mappedCitation-20299238 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299238 |
| http://purl.uniprot.org/uniprot/V9GZU2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20299238 |
| http://purl.uniprot.org/uniprot/P13500 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20299238 |