| http://purl.uniprot.org/citations/20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20299514 | http://www.w3.org/2000/01/rdf-schema#comment | "In inflamed venules, neutrophils rolling on E-selectin induce integrin alpha(L)beta(2)-dependent slow rolling on intercellular adhesion molecule-1 by activating Src family kinases (SFKs), DAP12 and Fc receptor-gamma (FcRgamma), spleen tyrosine kinase (Syk), and p38. E-selectin signaling cooperates with chemokine signaling to recruit neutrophils into tissues. Previous studies identified P-selectin glycoprotein ligand-1 (PSGL-1) as the essential E-selectin ligand and Fgr as the only SFK that initiate signaling to slow rolling. In contrast, we found that E-selectin engagement of PSGL-1 or CD44 triggered slow rolling through a common, lipid raft-dependent pathway that used the SFKs Hck and Lyn as well as Fgr. We identified the Tec kinase Bruton tyrosine kinase as a key signaling intermediate between Syk and p38. E-selectin engagement of PSGL-1 was dependent on its cytoplasmic domain to activate SFKs and slow rolling. Although recruiting phosphoinositide-3-kinase to the PSGL-1 cytoplasmic domain was reported to activate integrins, E-selectin-mediated slow rolling did not require phosphoinositide-3-kinase. Studies in mice confirmed the physiologic significance of these events for neutrophil slow rolling and recruitment during inflammation. Thus, E-selectin triggers common signals through distinct neutrophil glycoproteins to induce alpha(L)beta(2)-dependent slow rolling."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-12-259556"xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Maeda K."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Yao L."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Shao B."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "McEver R.P."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Miner J.J."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Coggeshall K.M."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Klopocki A.G."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/author | "Yago T."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/pages | "485-494"xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/title | "E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling."xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://purl.uniprot.org/core/volume | "116"xsd:string |
| http://purl.uniprot.org/citations/20299514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20299514 |
| http://purl.uniprot.org/citations/20299514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20299514 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTY7-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUH7-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVS1-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV23-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |
| http://purl.uniprot.org/uniprot/#_D3YW95-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |
| http://purl.uniprot.org/uniprot/#_D3YYP8-mappedCitation-20299514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20299514 |