| http://purl.uniprot.org/citations/20300111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20300111 | http://www.w3.org/2000/01/rdf-schema#comment | "Jun is essential for fetal development, as fetuses lacking Jun die at mid-gestation with multiple cellular defects in liver and heart. Embryos expressing JunD in place of Jun (Jun(d/d)) can develop to term with normal fetal livers, but display cardiac defects as observed in fetuses lacking Jun. Jun(d/d) mouse embryonic fibroblasts (MEFs) exhibit early senescence, which can be rescued by EGF and HB-EGF stimulation, probably through activation of Akt signaling. Thus, JunD cannot functionally replace Jun in regulating fibroblast proliferation. In Jun(-/-) fetal livers, increased hydrogen peroxide levels are detected and expression of Nrf1 and Nrf2 (nuclear erythroid 2-related transcription factors) is downregulated. Importantly, increased oxidative stress as well as expression of Nrf1 and Nrf2 is rescued by JunD in Jun(d/d) fetal livers. These data show that Jun is of critical importance for cellular protection against oxidative stress in fetal livers and fibroblasts, and Jun-dependent cellular senescence can be restored by activation of the epidermal growth factor receptor pathway."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2010.22"xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/author | "Wagner E.F."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/author | "Penninger J.M."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/author | "Kenner L."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/author | "Meixner A."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/author | "Karreth F."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/pages | "1409-1419"xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/title | "Jun and JunD-dependent functions in cell proliferation and stress response."xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/20300111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20300111 |
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