| http://purl.uniprot.org/citations/20303298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20303298 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammatory cytokines have been proposed to regulate epithelial homeostasis during intestinal inflammation. We report here that interferon-gamma (IFN-gamma) regulates the crucial homeostatic functions of cell proliferation and apoptosis through serine-threonine protein kinase AKT-beta-catenin and Wingless-Int (Wnt)-beta-catenin signaling pathways. Short-term exposure of intestinal epithelial cells to IFN-gamma resulted in activation of beta-catenin through AKT, followed by induction of the secreted Wnt inhibitor Dkk1. Consequently, we observed an increase in Dkk1-mediated apoptosis upon extended IFN-gamma treatment and reduced proliferation through depletion of the Wnt coreceptor LRP6. These effects were enhanced by tumor necrosis factor-alpha (TNF-alpha), suggesting synergism between the two cytokines. Consistent with these results, colitis in vivo was associated with decreased beta-catenin-T cell factor (TCF) signaling, loss of plasma membrane-associated LRP6, and reduced epithelial cell proliferation. Proliferation was partially restored in IFN-gamma-deficient mice. Thus, we propose that IFN-gamma regulates intestinal epithelial homeostasis by sequential regulation of converging beta-catenin signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.03.001"xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Skerra A."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Koch S."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Lee W.Y."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Capaldo C.T."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Laukoetter M.G."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Nava P."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Nusrat A."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Parkos C.A."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Neumaier I."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Beeman N."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Gerner-Smidt K."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Addis C."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/author | "Kolegraff K."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/pages | "392-402"xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/title | "Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/20303298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20303298 |
| http://purl.uniprot.org/citations/20303298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20303298 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-20303298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20303298 |