| http://purl.uniprot.org/citations/20305689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20305689 | http://www.w3.org/2000/01/rdf-schema#comment | "Mdm2 binding protein (MTBP) has been implicated in cell-cycle arrest and the Mdm2/p53 tumor suppressor pathway through its interaction with Mdm2. To determine the function of MTBP in tumorigenesis and its potential role in the Mdm2/p53 pathway, we crossed Mtbp-deficient mice to Emu-myc transgenic mice, in which overexpression of the oncogene c-Myc induces B-cell lymphomas primarily through inactivation of the Mdm2/p53 pathway. We report that Myc-induced B-cell lymphoma development in Mtbp heterozygous mice was profoundly delayed. Surprisingly, reduced levels of Mtbp did not lead to an increase in B-cell apoptosis or affect Mdm2. Instead, an Mtbp deficiency inhibited Myc-induced proliferation and the upregulation of Myc target genes necessary for cell growth. Consistent with a role in proliferation, Mtbp expression was induced by Myc and other factors that promote cell-cycle progression and was elevated in lymphomas from humans and mice. Therefore, Mtbp functioned independent of Mdm2 and was a limiting factor for the proliferative and transforming functions of Myc. Thus, Mtbp is a previously unrecognized regulator of Myc-induced tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2010.82"xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Iwakuma T."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Eischen C.M."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Arrate M.P."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Garriga J."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Lozano G."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Haines D.S."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Vincent T."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Odvody J."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/author | "Grieb B."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/pages | "3287-3296"xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/title | "A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis."xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20305689 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20305689 |
| http://purl.uniprot.org/citations/20305689 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20305689 |
| http://purl.uniprot.org/uniprot/#_E9Q0P8-mappedCitation-20305689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20305689 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-20305689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20305689 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-20305689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20305689 |
| http://purl.uniprot.org/uniprot/#_B1AUN8-mappedCitation-20305689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20305689 |
| http://purl.uniprot.org/uniprot/#_B1AUP0-mappedCitation-20305689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20305689 |