| http://purl.uniprot.org/citations/20307497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20307497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20307497 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of intracellular beta-catenin levels is central in the Wnt/beta-catenin signaling cascade and the activation of the Wnt target genes. Here, we show that homeodomain-interacting protein kinase 2 (HIPK2) acts as a negative regulator of the Wnt/beta-catenin pathway. Knock-down of endogenous HIPK2 increases the stability of beta-catenin and results in the accumulation of beta-catenin in the nucleus, consequently enhancing the expression of Wnt target genes and cell proliferation both in vivo and in cultured cells. HIPK2 inhibits TCF/LEF-mediated target gene activation via degradation of beta-catenin. HIPK2 phosphorylates beta-catenin at its Ser33 and Ser37 residues without the aid of a priming kinase. Substitutions of Ser33 and Ser37 for alanines abolished the degradation of beta-catenin associated with HIPK2. In ex vivo mouse model, HIPK2 knock-down resulted in accumulation of beta-catenin, thereby potentiated beta-catenin-mediated cell proliferation and tumor formation. Furthermore, the axis duplication induced by the ectopic expression of beta-catenin was blocked by co-injection of HIPK2 mRNAs into Xenopus embryos. Taken together, HIPK2 appears to function as a novel negative regulator of beta-catenin through its phosphorylation and proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.03.099"xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.03.099"xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Lee B.J."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Lee B.J."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Kim J.E."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Kim J.E."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Choi D.W."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Choi D.W."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Choi C.Y."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Choi C.Y."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Kim E.-A."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Kim E.-A."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Sung K.S."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/author | "Sung K.S."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/pages | "966-971"xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/pages | "966-971"xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/title | "Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/20307497 | http://purl.uniprot.org/core/title | "Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation."xsd:string |