| http://purl.uniprot.org/citations/20308060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20308060 | http://www.w3.org/2000/01/rdf-schema#comment | "We have recently shown that beta-catenin-facilitated export of cadherins from the endoplasmic reticulum requires PX-RICS, a beta-catenin-interacting GTPase-activating protein for Cdc42. Here we show that PX-RICS interacts with isoforms of 14-3-3 and couples the N-cadherin-beta-catenin complex to the microtubule-based molecular motor dynein-dynactin. Similar to knockdown of PX-RICS, knockdown of either 14-3-3zeta or - resulted in the disappearance of N-cadherin and beta-catenin from the cell-cell boundaries. Furthermore, we found that PX-RICS and 14-3-3zeta/ are present in a large multiprotein complex that contains dynein-dynactin components as well as N-cadherin and beta-catenin. Both RNAi- and dynamitin-mediated inhibition of dynein-dynactin function also led to the absence of N-cadherin and beta-catenin at the cell-cell contact sites. Our results suggest that the PX-RICS-14-3-3zeta/ complex links the N-cadherin-beta-catenin cargo with the dynein-dynactin motor and thereby mediates its endoplasmic reticulum export."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.081315"xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Iemura S."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Matsuura K."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Mimori-Kiyosue Y."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/author | "Sakaue F."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/pages | "16145-16154"xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/title | "The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum."xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20308060 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20308060 |
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